About

Founded in 2010, Cold Genesys is a privately-held, clinical-stage biopharmaceutical company focused on the research, acquisition and development of novel immunotherapies.

We employ a capital-efficient operating model to achieve expedited product approval. Our strategy is centered on providing patients with new and impactful therapies. Our lead proprietary agent, CG0070, has the potential to deliver safe and effective cancer care alone and in combination with other immunotherapies. CG0070 has been shown to be a safe agent in BCG-failure non-muscle invasive bladder cancer (NMIBC) and we are exploring further types of cancer in clinical studies. At Cold Genesys, we aim to take the next evolutionary step in delivering innovative cancer care to millions of patients in need worldwide.

In 2010, Cold Genesys acquired the global rights to CG0070 from BioSante Pharmaceuticals. Cold Genesys is currently investigating the company’s first product, CG0070, for the treatment of non-muscle invasive bladder cancer in the BCG-unresponsive patient population. In addition, Cold Genesys is exploring the use of CG0070 in combination with immune checkpoint modulators (ICMs) in various solid tumors.

Management

Arthur Kuan

Chief Executive Officer

Arthur currently serves as Chief Executive Officer and Director on the Board at Cold Genesys, a privately-held, clinical-stage biopharmaceutical company focused on the research, acquisition and development of novel immunotherapies, including an oncolytic virus for the treatment of bladder cancer and a variety of other solid tumor types. Arthur is a Founding Member of Ally Bridge Group, a global healthcare-focused investment platform, and plays an active role in managing the fund’s portfolio companies. Previously, Arthur was a member of Themes Investment Partners, a Private Equity fund based in Hong Kong, where he played a central role in coordinating cross-border technology transfer and regulatory submissions for portfolio companies. He began his career in an operational role at Dinova Capital, a Shanghai-based, medical technology incubator fund, evaluating medical device investment opportunities. Arthur received his M.S. in Biotechnology from the Johns Hopkins University and his B.A. in Biology from the University of Pennsylvania.​

Paola Grandi, Ph.D.

Chief Scientific Officer

Paola is widely regarded as a scientific leader in the field of immuno-oncology and is responsible for directing the clinical and translational research program at Cold Genesys. Paola earned a Ph.D. in Biochemistry from the University of Ferrara (Italy) in 2001 before moving to the U.S. to pursue her interests in oncolytic Herpes Simplex Virus-based vectors for the treatment of recurrent malignant glioblastoma. After four years of post-doctoral research at the Massachusetts General Hospital in Boston, Paola joined the Departments of Neurological Surgery and Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine where she developed the next-generation Oncolytic HSV-based vectors armed with novel payload combinations that altered the tumor microenvironment (TME) to promote the development of anti-tumor immunity. As an NIH funded principal investigator, she carried out pioneering work to combine the use of retargeted HSV vectors with cellular microRNA regulation of viral genes in non-tumor tissue to limit vector oncolytic activity to brain tumors. Her academic research produced several key patents that provided the core technologies to establish a start-up oncolytic vector company, Oncorus, Inc. in Cambridge, MA as company co-founder, scientific advisory board member and early stage director of company research.​

Bing Kung

Vice President, Business Development

Bing has over fourteen years of life science industry experience as a business development executive, investment banker and scientist. He has been involved in over 75 partnership, M&A and financing transactions in the life science sector, including those for immuno-oncology and platform technology companies. Most recently, Bing managed business development activities at Ascendancy Healthcare, which provided Western-based companies partnership solutions enabling entry and commercialization of their biopharmaceutical products into China and other high-growth Asian markets. Previously, he served as Vice President at Torreya Partners, a boutique life science investment bank, and also worked at MTS Health Partners and Aquilo Partners. Bing began his career as a research scientist in the Divisions of Oncology and Neurology at The Children's Hospital of Philadelphia, where he authored a number of peer-reviewed publications on the molecular basis of the pediatric solid tumor neuroblastoma. He received his Master's in Biotechnology and his Bachelor’s in Biology from the University of Pennsylvania.

Amy Steele

Vice President, Controller

Amy joined Cold Genesys as Vice President, Controller in July 2016 and is responsible for Gold Genesys’ global finance and accounting activities. Prior to joining Cold Genesys, she served as the Associate Director, Finance & Business Operations at TWi Pharmaceuticals USA, Inc. and Genovi Pharmaceuticals, Inc. and was responsible for setting up of multiple corporate entities in the US, UK and Taiwan, implementing global ERP system, obtaining state wholesale and virtual manufacturing licenses for generic products as well as transfer pricing analysis. Amy brings many years of experience in financing, accounting and internal audit and received her B.A. degree in Business Economics / Accounting from University of California Los Angeles.

Bradley Grimm

Senior Director, Manufacturing

Brad has worked in the life sciences industry for over 25 years, with a specific focus on viral-based therapeutics and vaccines. Brad began his career in this field at Chiron Therapeutics’ gene therapy division in San Diego, performing all aspects of their retroviral production process, from initial cell culture through final product lyophilization. In addition to over a decade of work in the Process Development and cGMP Manufacturing departments at Chiron, Brad also worked at GenStar Therapeutics, performing process optimization and cGMP tech transfer for their adenovirus-based therapies, as well as Telos Pharmaceuticals, where he focused on development of cell culture systems for activated T-cell lines. Most recently prior to joining the Somatek consulting group, Brad spent twelve years as a Process Development scientist at MilliporeSigma’s viral vaccine and gene therapy Contract Manufacturing facility. In this capacity, he helped develop and optimize production processes for multiple clients and oversaw their transfer for successful cGMP Manufacturing production.

Board of Directors

Arthur Kuan

Chief Executive Officer

Arthur currently serves as Chief Executive Officer and Director on the Board at Cold Genesys, a privately-held, clinical-stage biopharmaceutical company focused on the research, acquisition and development of novel immunotherapies, including an oncolytic virus for the treatment of bladder cancer and a variety of other solid tumor types. Arthur is a Founding Member of Ally Bridge Group, a global healthcare-focused investment platform, and plays an active role in managing the fund’s portfolio companies. Previously, Arthur was a member of Themes Investment Partners, a Private Equity fund based in Hong Kong, where he played a central role in coordinating cross-border technology transfer and regulatory submissions for portfolio companies. He began his career in an operational role at Dinova Capital, a Shanghai-based, medical technology incubator fund, evaluating medical device investment opportunities. Arthur received his M.S. in Biotechnology from the Johns Hopkins University and his B.A. in Biology from the University of Pennsylvania.

Ronald Cheng

Managing Director, Wellchamp Capital

Ronald has more than 20 years of experience in the Finance and Investment realm with an emphasis in media and biotechnology. He is the Founder and Managing Director at Wellchamp Capital Limited, a Hong Kong SFC registered asset management and investment advisory firm. In 2002, Ronald was Investor and Director of Plasmagene Bioscience, a biotechnology company founded by Dr. Alex Yeung, which eventually became listed as a part of the Hong Kong Stock Exchange (SEHK). Ronald was also Investor and Director of New Media Corp, a telecommunications media company invested in news and publication since 1975. Ronald holds a B.S. from The Chinese University of Hong Kong in Business Administration.

Jim Mulé, Ph.D.

Director of Cell-based Therapies, Moffitt Cancer Center

Jim is Associate Center Director, the U.S. Senator Connie Mack (ret.) & Family Endowed Chair for Melanoma Research and Treatment, and Director of Cell-based Therapies at the Moffitt Cancer Center, Tampa, Florida. He is recognized for his research and clinical trial contributions to cancer immunotherapy, particularly in melanoma. His translational work in this area has helped to develop new treatments for advanced cancer patients. He has published nearly 200 articles. Jim serves on Advisory Boards of numerous biotechnology and pharma companies as well as investment funds (e.g., OncoPep, Fulgent Diagnostics, UbiVac, Lion Biotech, Orpheus Therapeutics, Vault Pharma, Celgene, Select BioVenture Partners, Noble Life Science Partners, among others). Jim remains a long-standing special government employee to the FDA (CDER and CBER) and the NCI. He was Chair of the Cellular, Tissue, and Gene Therapy Advisory Committee of CBER, FDA. He currently serves on the advisory boards of several NCI-designated Cancer Centers and was a member of the NCI Director’s Board of Scientific Counselors (BSC-A). Jim also serves on the Editorial Boards of several peer-reviewed journals, including Scientific Reports (nature.com), Journal of Immunotherapy, and Cancer Immunology Research (AACR). Jim received his professional degrees from the Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington. He then received his formal postgraduate training at the Surgery Branch, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland, where he became a Senior Investigator with tenure. Jim moved to Palo Alto, CA, where he helped to launch and scientifically direct two biotechnology companies and was also an adjunct professor at Stanford University. He then moved to Ann Arbor, Michigan to become the Director of the Tumor Immunology and Immunotherapy Program at the University of Michigan Comprehensive Cancer Center, the Maude T. Lane Endowed Professor of Surgery with tenure, Department of Surgery, and Professor in the Department of Internal Medicine.

Leonard Post, Ph.D.

Chief Scientific Officer, Vivace Therapeutics

Len has over three decades of pharmaceutical R&D experience. He is currently Chief Scientific Officer at Vivace Therapeutics. Previous experience included roles as Chief Scientific Officer of BioMarin, Chief Scientific Officer of LEAD Therapeutics, SVP of R&D at Onyx Pharmaceuticals, and positions at Parke-Davis and Upjohn. His experience with oncolytic viruses began with the adenovirus program at Onyx, and later as a member of the Boards of Directors of BioVex and then Viralytics. He is currently a member of the boards of directors at Vivace, Orphagen, Fedora, and Oxyrane. Len has a Ph.D. in Biochemistry and did postdoctoral work in virology, including some of the early work on genetic engineering of herpes simplex virus.

Jue Pu

Lepu Medical

Jue leads the cancer biomarker and liquid biopsy research and development at Lepu Medical. She also leads international investment for Lepu Medical, with successful investments including Viralytics (acquired by Merck). Jue holds a Master of Science degree in Materials Science Engineering at Stanford University. She holds a dual undergraduate degree, summa cum laude, from the Wharton School of Finance and Materials Science Engineering at the University of Pennsylvania.

Simone Song

Senior Partner, ORI Capital

Simone is Founder and Senior Partner of ORI Capital. She was the former Head of Goldman Sachs Healthcare Investment Banking for Greater China. Simone has more than 25 years of experience in healthcare sector. Prior to joining Goldman Sachs, she was a Managing Director of Cowen Group, a member of the advisory board of AXA Investment Managers, and an executive board advisor to AXA Asia Pacific Holdings. Simone holds a B.A. in Economics from Fudan University in China and an M.A. in Economics from Claremont Graduate School in the United States.

Contact

Cold Genesys, Inc.

400 Spectrum Center Drive
​Suite #2040
​Irvine, CA 92618